Publications

Pubmed Search Result

2017

Ruedas JB and Connor JH. Generating Recombinant Vesicular Stomatitis Viruses for Use as Vaccine Platforms. Recombinant Virus Vaccines: Methods and Protocols. 2017. Springer New York. doi: 10.1007/978-1-4939-6869-5_12


Rossignol ED, Peters KN, Connor JH, Bullitt E. Zika Virus Induced Cellular Remodeling. Cell Microbiol. 2017 Mar 20. doi: 10.1111/cmi.12740.


Ünlü NL, Kanik FE, Seymour E, Connor JH, Ünlü MS. DNA-Directed Antibody Immobilization for Robust Protein Microarrays: Application to Single Particle Detection DNA-Directed Antibody Immobilization. Methods Mol Biol. 2017;1571:187-206. doi: 10.1007/978-1-4939-6848-0_12.


Scherr SM, Freedman DS, Agans KN, Rosca A, Carter E, Kuroda M, Fawcett HE, Mire CE, Geisbert TW, Ünlü MS, Connor JH. Disposable cartridge platform for rapid detection of viral hemorrhagic fever viruses. Lab Chip. 2017 Feb 28;17(5):917-925. doi: 10.1039/c6lc01528j.


Liu X, Speranza E, Muñoz-Fontela C, Haldenby S, Rickett NY, Garcia-Dorival I, Fang Y, Hall Y, Zekeng EG, Lüdtke A, Xia D, Kerber R, Krumkamp R, Duraffour S, Sissoko D, Kenny J, Rockliffe N, Williamson ED, Laws TR, N'Faly M, Matthews DA, Günther S, Cossins AR, Sprecher A, Connor JH, Carroll MW, Hiscox JA. Transcriptomic signatures differentiate survival from fatal outcomes in humans infected with Ebola virus. Genome Biol. 2017 Jan 19;18(1):4. doi: 10.1186/s13059-016-1137-3.


Olsen ME, Connor JH. Hypusination of eIF5A as a Target for Antiviral Therapy. DNA Cell Biol. 2017 Jan 12. doi: 10.1089/dna.2016.3611.


2016

Wilson MR, Fedewa G, Stenglein MD, Olejnik J, Rennick LJ, Nambulli S, Feldmann F, Duprex WP, Connor JH, Mühlberger E, DeRisi JL. Multiplexed Metagenomic Deep Sequencing To Analyze the Composition of High-Priority Pathogen Reagents. mSystems. 2016 July 19;1(4). pii: e00058-16.


Fawcett H, Ünlü MS, Connor JH. New Approaches for Virus Detection through Multidisciplinary Partnerships. ASC Infectious Diseases. 2016 June 10;2(6):378-81. doi: 10.1021/acsinfecdis.6b00063.


Caballero IS, Honko AN, Gire SK, Winnicki SM, Melé M, Gerhardinger C, Lin AE, Rinn JL, Sabeti PC, Hensley LE, Connor JH. In vivo Ebola virus infection leads to a strong innate response in circulating immune cells. BMC Genomics. 2016 Sep 5;17:707. doi: 10.1186/s12864-016-3060-0.


Olsen ME, Filone CM, Rozelle D, Mire CE, Agans KN, Hensley L, Connor JH. Polyamines and Hypusination Are Required for Ebolavirus Gene Expression and Replication. MBio. 2016 July 26;7(4). pii: e00882-16. doi: 10.1128/mBio.00882-16.


Scherr SM, Daaboul GG, Trueb J, Sevenler D, Fawcett H, Goldberg B, Connor JH, Ünlü MS. Real-Time Capture and Visualization of Individual Viruses in Complex Media. ACS Nano. 2016 Feb. 23;10(2):2827-33. doi: 10.1021/acsnano.5b07948. Epub 2016 Jan 22.


2015

Seymour E, Daaboul GG, Zhang X, Scherr SM, Ünlü NL, Connor JH, Ünlü MS. DNA-Directed Antibody Immobilization for Enhanced Detection of Single Viral Pathogens. Analytical Chemistry. 2015 Oct 20;87(20):10505-12. doi: 10.1021/acs.analchem.5b02702. Epub 2015 Oct 7.


Connor JH, Yen J, Caballero IS, Garamszegi S, Malhotra S, Lin K, Hensley L, Goff AJ. Transcriptional Profiling of the Immune Response to Marburg Virus Infection. Journal of Virology. 2015 Oct;89(19):9865-74. doi: 10.1128/JVI.01142-15. Epub 2015 Jul 22.


Lin KL, Twenhafel NA, Connor JH, Cashman KA, Shamblin JD, Donnelly GC, Esham HL, Wlazlowski CB, Johnson JC, Honko AN, Botto MA, Yen J, Hensley LE, Goff AJ. Temporal Characterization of Marburg Virus Angola Infection following Aerosol Challenge in Rhesus Macaques. Journal of Virology. 2015 Oct;89(19):9875-85. doi: 10.1128/JVI.01147-15. Epub 2015 Jul 22.


Mire CE, Geisbert JB, Versteeg KM, Mamaeva N, Agans KN, Geisbert TW, Connor JH. A Single-Vector, Single-Injection Trivalent Filovirus Vaccine: Proof of Concept Study in Outbred Guinea Pigs. Journal of Infectious Diseases. 2015 Oct 1;212 Suppl 2:S384-8. doi: 10.1093/infdis/jiv126. Epub 2015 May 9.


Filone CM, Dower K, Cowley GS, Hensley LE, Connor JH. Probing the virus host interaction in high containment: an approach using pooled short hairpin RNA. ASSAY and Drug Development Technologies. 2015 Jan-Feb;13(1):34-43. doi: 10.1089/adt.2014.613. Epub 2015 Feb 3.


2014

Caballero IS, Yen JY, Hensley LE, Honko AN, Goff AJ, Connor JH. Lassa and Marburg viruses elicit distinct host transcriptional responses early after infection. BMC Genomics. 2014 Nov 6;15:960. doi: 10.1186/1471-2164-15-960.


Garamszegi S, Yen JY, Honko AN, Geisbert JB, Rubins KH, Geisbert TW, Xia Y, Hensley LE, Connor JH. Transcriptional correlates of disease outcome in anticoagulant-treated non-human primates infected with ebolavirus. PloS Neglacted Tropical Diseases. 2014 Jul 31;8(7):e3061. doi: 10.1371/journal.pntd.0003061. eCollection 2014.


Chung DH, Jonsson CB, Tower NA, Chu YK, Sahin E, Golden JE, Noah JW, Schroeder CE, Sotsky JB, Sosa MI, Cramer DE, McKellip SN, Rasmussen L, White EL, Schmaljohn CS, Julander JG, Smith JM, Filone CM, Connor JH, Sakurai Y, Davey RA. Discovery of a novel compound with anti-venezuelan equine encephalitis virus activity that targets the nonstructural protein 2. PloS Pathogens. 2014 Jun 26;10(6):e1004213. doi: 10.1371/journal.ppat.1004213. eCollection 2014.


Gammon DB, Duraffour S, Rozelle DK, Hehnly H, Sharma R, Sparks ME, West CC, Chen Y, Moresco JJ, Andrei G, Connor JH, Conte D Jr, Gundersen-Rindal DE, Marshall WL, Yates JR, Silverman N, Mello CC. A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection. eLife. 2014 Jun 25;3. doi: 10.7554/eLife.02910.


Rozelle DK, Filone CM, Dower K, Connor JH. Vaccinia reporter viruses for quantifying viral function at all stages of gene expression. Journal of Visualized Experiments. 2014 May 15;(87). doi: 10.3791/51522.


Daaboul GG, Lopez CA, Chinnala J, Goldberg BB, Connor JH, Unlü MS. Digital sensing and sizing of vesicular stomatitis virus pseudotypes in complex media: a model for Ebola and Marburg detection. ACS Nano. 2014 Jun 24;8(6):6047-55. doi: 10.1021/nn501312q. Epub 2014 Jun 4.


Rozelle DK, Filone CM, Kedersha N, Connor JH. Activation of stress response pathways promotes formation of antiviral granules and restricts virus replication. Molecular Cell Biology. 2014 Jun;34(11):2003-16. doi: 10.1128/MCB.01630-13. Epub 2014 Mar 24.


2013

Reddington AP, Trueb JT, Freedman DS, Tuysuzoglu A, Daaboul GG, Lopez CA, Karl WC, Connor JH, Fawcett H, Ünlu MS. An interferometric reflectance imaging sensor for point of care viral diagnostics. Transactions on Biomedical Engineering. 2013 Dec;60(12):3276-83. doi: 10.1109/TBME.2013.2272666.


Malhotra S, Yen JY, Honko AN, Garamszegi S, Caballero IS, Johnson JC, Mucker EM, Trefry JC, Hensley LE, Connor JH. Transcriptional profiling of the circulating immune response to lassa virus in an aerosol model of exposure. PLOS Neglacted Tropical Diseases. 2013 Apr 25;7(4):e2171. doi: 10.1371/journal.pntd.0002171. Print 2013.


Filone CM, Hodges EN, Honeyman B, Bushkin GG, Boyd K, Platt A, Ni F, Strom K, Hensley L, Snyder JK, Connor JH. Identification of a broad-spectrum inhibitor of viral RNA synthesis: validation of a prototype virus-based approach. Chemistry & Biology. 2013 Mar 21;20(3):424-33. doi: 10.1016/j.chembiol.2013.02.011.


Chan WM, Bartee EC, Moreb JS, Dower K, Connor JH, McFadden G. Myxoma and vaccinia viruses bind differentially to human leukocytes. Journal of Virology. 2013 Apr;87(8):4445-60. doi: 10.1128/JVI.03488-12. Epub 2013 Feb 6.


Hodges EN, Connor JH. Translational control by negative-strand RNA viruses: methods for the study of a crucial virus/host interaction. Methods. 2013 Feb;59(2):180-7. doi: 10.1016/j.ymeth.2012.09.003. Epub 2012 Sep 23.


2012

Hodges EN, Heinrich BS, Connor JH. A vesiculovirus showing a steepened transcription gradient and dominant trans-repression of virus transcription. Journal of Virology. 2012 Aug;86(16):8884-9. doi: 10.1128/JVI.00358-12. Epub 2012 Jun 6.


Dunn EF, Connor JH. HijAkt: The PI3K/Akt pathway in virus replication and pathogenesis. Progress in Molecular Biology and Translational Science. 2012;106:223-50. doi: 10.1016/B978-0-12-396456-4.00002-X.


Johnston SC, Lin KL, Connor JH, Ruthel G, Goff A, Hensley LE. In vitro inhibition of monkeypox virus production and spread by Interferon-β. Virology Journal. 2012 Jan 6;9:5. doi: 10.1186/1743-422X-9-5.


Yurt A, Daaboul GG, Connor JH, Goldberg BB, Ünlü MS. Single nanoparticle detectors for biological applications. Nanoscale. 2012 Feb 7;4(3):715-26. doi: 10.1039/c2nr11562j. Epub 2012 Jan 3.


Dower K, Filone CM, Hodges EN, Bjornson ZB, Rubins KH, Brown LE, Schaus S, Hensley LE, Connor JH. Identification of a pyridopyrimidinone inhibitor of orthopoxviruses from a diversity-oriented synthesis library. Journal of Virology. 2012 Mar;86(5):2632-40. doi: 10.1128/JVI.05416-11. Epub 2011 Dec 28.


2011

Yen JY, Garamszegi S, Geisbert JB, Rubins KH, Geisbert TW, Honko A, Xia Y, Connor JH, Hensley LE. Therapeutics of Ebola hemorrhagic fever: whole-genome transcriptional analysis of successful disease mitigation. Journal of Infectious Diseases. 2011 Nov;204 Suppl 3:S1043-52. doi: 10.1093/infdis/jir345.


Yanik AA, Cetin AE, Huang M, Artar A, Mousavi SH, Khanikaev A, Connor JH, Shvets G, Altug H. Seeing protein monolayers with naked eye through plasmonic Fano resonances. PNAS. 2011 Jul 19;108(29):11784-9. doi: 10.1073/pnas.1101910108. Epub 2011 Jun 29.


Lopez CA, Daaboul GG, Ahn S, Reddington AP, Monroe MR, Zhang X, Irani RJ, Yu C, Genco CA, Cretich M, Chiari M, Goldberg BB, Connor JH, Ünlü MS. Biomolecular detection employing the Interferometric Reflectance Imaging Sensor (IRIS). Journal of Visualized Experiments. 2011 May 3;(51). pii: 2694. doi: 10.3791/2694.


Dower K, Rubins KH, Hensley LE, Connor JH. Development of Vaccinia reporter viruses for rapid, high content analysis of viral function at all stages of gene expression. Antiviral Research. 2011 Jul;91(1):72-80. doi: 10.1016/j.antiviral.2011.04.014. Epub 2011 May 5.


Lopez CA, Daaboul GG, Vedula RS, Ozkumur E, Bergstein DA, Geisbert TW, Fawcett HE, Goldberg BB, Connor JH, Unlü MS. Label-free multiplexed virus detection using spectral reflectance imaging. Biosensors and Bioelectric. 2011 Apr 15;26(8):3432-7. doi: 10.1016/j.bios.2011.01.019. Epub 2011 Jan 22.


Simpson-Holley M, Kedersha N, Dower K, Rubins KH, Anderson P, Hensley LE, Connor JH. Formation of antiviral cytoplasmic granules during orthopoxvirus infection. Journal of Virology. 2011 Feb;85(4):1581-93. doi: 10.1128/JVI.02247-10. Epub 2010 Dec 8.


2010

Yanik AA, Huang M, Kamohara O, Artar A, Geisbert TW, Connor JH, Altug H. An optofluidic nanoplasmonic biosensor for direct detection of live viruses from biological media. Nano Letters. 2010 Dec 8;10(12):4962-9. doi: 10.1021/nl103025u. Epub 2010 Nov 5.


Dunn EF, Connor JH. Dominant inhibition of Akt/protein kinase B signaling by the matrix protein of a negative-strand RNA virus. Journal of Virology. 2011 Jan;85(1):422-31. doi: 10.1128/JVI.01671-10. Epub 2010 Oct 27.


Smith DR, McCarthy S, Chrovian A, Olinger G, Stossel A, Geisbert TW, Hensley LE, Connor JH. Inhibition of heat-shock protein 90 reduces Ebola virus replication. Antiviral Research. 2010 Aug;87(2):187-94. doi: 10.1016/j.antiviral.2010.04.015. Epub 2010 May 7.


2009

Dunn EF, Fearns R, Connor JH. Akt inhibitor Akt-IV blocks virus replication through an Akt-independent mechanism. Journal of Virology. 2009 Nov;83(22):11665-72. doi: 10.1128/JVI.01092-09. Epub 2009 Sep 9.